Senior Director, Scientific Project Lead (Cardio-Renal-Metabolic)

The Role: 

Generate is seeking a Senior Director,  Scientific  Project Lead,   Cardio-Renal-Metabolic  to lead complex, cross-functional scientific programs from concept and early discovery through preclinical proof-of-concept, contribute to translational and early development strategy, and manage and develop scientific talent.  

This role combines formal people management with broad cross-functional leadership across research, platform, translational, development, and portfolio functions. Working closely with functional , business and technical  leaders,  project managers ,  and senior and executive stakeholders, the  Scientific  Project Lead   will bring scientific judgment   in therapeutic discovery , strategic program leadership, and operational rigor to align multidisciplinary teams, guide key decisions, represent programs in governance forums, and contribute to portfolio prioritization.  

Here's how you will contribute:

Lead complex programs from concept and early discovery through preclinical proof-of-concept, with accountability for scientific strategy, execution quality, team effectiveness, risk management, and stage-gate readiness.  

Develop and  maintain  integrated program strategies and plans that align scientific  objectives , timelines, and resourcing.  

Set  scientific  program direction,  identify  and advance therapeutic opportunities and target proposals by integrating biology, Generate’s differentiated platform capabilities, internal and external evidence, translational and clinical rationale, and competitive intelligence.  

Facilitate cross-functional discussions, resolve divergent perspectives, make clear recommendations, own key  scientific   decisions within the  project  team structure, and drive  timely  go/no-go recommendations.  

Drive execution across wet  lab , computational,  platform , and translational workstreams, ensuring scientific rigor, reproducibility, strong documentation, and high-quality data packages.  

Develop resource plans and budget assumptions,  anticipate  strategic inflection points, and proactively resolve risks, gaps, and cross-functional dependencies.  

Build effective operating mechanisms for program planning, governance preparation, risk tracking, decision-making, and cross-functional accountability.  

Manage, coach, and develop direct reports through clear  objectives , regular feedback, performance management, and career development; mentor cross-functional team members in partnership with their functional managers.  

Set clear expectations and foster a high-performing  team  culture grounded in scientific rigor, accountability, transparency, urgency, collaboration, and constructive challenge.  

The Ideal Candidate will have:

PhD, MD, or MD/PhD in the life sciences or another discipline relevant to therapeutic discovery and development.  

12+ years of r elevant  experience in biotech, pharma, academia, or a related scientific environment.  

Experience  identifying , evaluating,  and  advancing therapeutic targets and programs in cardio-renal-metabolic diseases  or related areas , including relevant  in vitro and in vivo  preclinical  models  and translational considerations such as biomarkers and PK/PD.  

Demonstrated success advancing complex programs across discovery and translational stages, including stage-gate reviews, prioritization decisions, and early development planning.  

Experience managing and developing scientists or other technical professionals, together with a strong record of leading multidisciplinary teams through influence.  

Strong scientific grounding in biology, experimental design, data interpretation, and synthesis across multiple technical domains.  

A track record  of identifying, evaluating, and advancing novel targets or therapeutic opportunities with strong biological and translational rationale.  

Experience shaping program strategy, influencing senior stakeholders, and driving …