AI Hiring Index

Unlearn · Engineering · Lead / Manager · Posted 2026-09-17

VP of Engineering

Unlearn · San Francisco · $260k–310k base

This range's midpoint is above 79% of posted engineering ranges at AI companies right now. See the salary index.

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OUR MISSION AND VISION

Unlearn exists to transform clinical development by making every trial smarter. We harness data, AI, and digital twins to enable faster, more robust studies that bring life-saving treatments to patients faster. This mission drives everything we do as we partner with biopharmaceutical companies to redesign how clinical trials are planned, run, and analyzed.

We are defining the future of clinical development with unmatched scientific credibility, replacing uncertainty with AI-powered precision so decisions are clearer and trials are stronger. We don’t just disrupt the pharmaceutical industry, we create lasting change.

We believe AI will define the future of medicine, and we are committed to building that future responsibly, rigorously, and in close collaboration with our partners in clinical development.

ABOUT OUR TEAM

We come from a variety of backgrounds ranging from machine learning to marketing—but regardless of where we come from, Unlearners share some common traits:

- Unlearners are ambitious; we aren’t intimidated by big, challenging goals.

- Unlearners are disciplined experimenters; we break down our big goals into smaller chunks and meet as often as necessary to track our velocity and iterate quickly.

- Unlearners are gritty; we never give up, setbacks just make us try harder.

- Unlearners are receptive to new ideas; in fact, we hate being stuck with the status quo

- Unlearners are storytellers; sharing information with each other and with the world is super important, too important to be boring. And, last but not least,

- Unlearners are team-oriented; we put the mission first, the company second, the team third, and individuals last.

Headquartered in San Francisco, Unlearn was founded in 2017 by a team of world-class machine learning scientists. We have raised venture capital from top tier investors such as Altimeter, Insight Partners, Radical Ventures, 8VC, DCVC, and DCVC Bio, and completed our $50 million Series C in January 2024.

If our purpose and culture resonate with you, we invite you to apply.

YOUR ROLE

Leading Pharma and Biotech companies trust Unlearn to deliver scientifically rigorous work using digital twins on studies where the stakes are high and the timelines are real. A digital twin of a patient is a comprehensive prediction of expected outcomes under a defined standard of care, made by a machine learning model built using our proprietary technology. Working at scale across the industry requires a strong engineering foundation built around data, models, and AI in a regulated, compliance-heavy environment.

As the VP of Engineering, you will lead our engineering function, an organization of engineers spanning core engineering, applications, ML/AI Ops, and infrastructure. The team includes engineers across experience levels, anchored by strong senior technical leaders. Engineering plays a critical role in our ability to deliver AI technology through models, applications, and agentic systems, and this role will ensure the potential of AI systems are realized across that technical stack.

This is an execution-focused leadership role, focused on the core engineering systems, software applications, infrastructure, and forward deployment that drive AI-heavy, tech-enabled services. You will work with your teams on scoping and delivery, and lead an engineering organization known for shipping what it commits to. You will partner closely with Product, Delivery, and R&D teams to understand requirements, integrate engineering with our customer delivery teams, and build the platform and tools they use to do their best work.

Just as importantly, you will connect engineering to the company's direction, understanding company strategy, translating it into a concrete engineering roadmap that integrates a workflow across data, modeling, applications, compliance, and security, and holding the team accountable for delivering to that roadmap on timeframes that match company objecti …

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